A 65-year-old male presents with a painful left finger, he

A 65-year-old male presents with a painful left finger, he is unable to bend it and it is significantly swollen.  He has a history of osteoarthritis.OA is a disease of articular cartilage and subchondral bone in diarthrodial joints. Please explain. What is the role of osteophytes in OA? How do NSAIDS affect OA? How does weight loss affect OA?

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